MK-0557 from CAYMAN CHEMICAL COMPANY
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| Product Name | MK-0557 |
| Description | A potent antagonist of NPY receptor Y5 (Kis = 1.3, 0.79, 0.74, and 1.4 nM for human, rhesus monkey, mouse, and rat receptors, respectively); >7,500-fold selective for Y5 over other NPY receptors and lacks activity in a panel of 180 receptors, enzymes, and ion channels at concentrations up to 1 µM; increases intracellular calcium in CHO cells expressing the human Y5 receptor in a concentration-dependent manner; reduces body weight gain in wild-type and diet-induced obese mice when administered at a dose of 30 mg/kg; reduces retroperitoneal fat pad weight, epididymal and mesenteric fat pad weights, leptin levels, and food intake in lean mice fed a high-fat diet |
| Size | 10 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | 935765-76-7 MK0557 Y-5 Chinese ovary hamster |
| Gene, Accession, CAS # | CAS: 328232-95-7 |
| Catalog # | 22134-10 |
| Price | $283.00 |
| Order / More Info | MK-0557 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
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