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Product Name | DPTIP (hydrochloride) |
Description | An nSMase2 inhibitor (IC50 = 30 nM); selective for nSMase2 over ALP and acid sphingomyelinase (IC50s = >100 µM for both); reduces viral yield in Vero and HeLa cells infected with West Nile virus (EC50s = 0.26 and 2.81 µM, respectively) or Zika virus (EC50s = 1.56 and 1.84 µM, respectively); prevents serum deprivation-induced astrocyte activation in primary rat astrocytes at 10 µM; reduces IL-1β-induced extracellular vesicle release from astrocytes, decreases neutrophil infiltration to the brain, and reduces hepatic levels of Ccl2, Tnf-α, Il-6, and Il-1β in a GFAP-GFP mouse model of inflammation-induced brain injury at 10 mg/kg, |
Size | 5 mg |
Concentration | n/a |
Applications | n/a |
Other Names | 351353-48-5 nSM ase2 IL1β GFAPGFP CCmotif Cc l2 C cl2 Il6 Tnfα |
Gene, Accession, CAS # | CAS: 2361799-64-4 |
Catalog # | 41681-5 |
Price | $99.00 |
Order / More Info | DPTIP (hydrochloride) from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |