MK-0752 from CAYMAN CHEMICAL COMPANY
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| Product Name | MK-0752 |
| Description | A potent, reversible inhibitor of γ-secretase, reducing the cleavage of APP to Aβ40 in SH-SY5Y cells with an IC50 value of 5 nM; orally bioavailable and crosses the blood-brain barrier, as orally administered MK-0752 dose-dependently reduces the generation of new amyloid β protein in the brain of rhesus monkeys |
| Size | 10 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | 952578-?68-?6 656810-87-6 biochemical inhibitor inhibit Alzheimer's research neuroscience cancer stem cell research MK0752 potent γ-secretase protease complex cleave single-pass transmembrane protein Notch receptor precursor β-amyloid APP domain reversible Aβ40 Aβ-40 cleavage reduce human neuroblastoma SH-SY5Y SHSY5Y orally bioavailable blood-brain barrier dose-dependently generation new rhesus monkey pathway breast cancer tumorgraft chemotherapy drug docetaxel mice tumor |
| Gene, Accession, CAS # | CAS: 471905-41-6 |
| Catalog # | 16706-10 |
| Price | $435.00 |
| Order / More Info | MK-0752 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
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