CAY10746 from CAYMAN CHEMICAL COMPANY
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| Product Name | CAY10746 |
| Description | A ROCK1 and ROCK2 inhibitor (IC50s = 14 and 3 nM, respectively); selective for ROCK1 and ROCK2 over PKA (IC50 = >10,000 nM) and over 387 recombinant human protein kinases in a panel of 394 kinases (IC50s = >10,000 nM for all) but does inhibit LIMK2, Aurora A, Aurora B, PKG1α, and PKG1β (IC50s = 46, 1,072, 1,239, 517, and 660 nM, respectively); inhibits phosphorylation of MYPT1 in SH-SY5Y cells at 0.1-10 µM; inhibits HUVEC migration at 1 µM; protects isolated mouse retinal neurons from apoptosis and oxidative stress induced by high glucose in an in vitro model of diabetic retinopathy; promotes high glucose-induced vessel regression in mouse retinal explants |
| Size | 500 µg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | CAY-10746 LIMK-2 PKG-1α 1β MYPT-1 SHSY5Y |
| Gene, Accession, CAS # | CAS: 2247240-76-0 |
| Catalog # | 29814-500 |
| Price | $153.00 |
| Order / More Info | CAY10746 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
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