XL184 from CAYMAN CHEMICAL COMPANY
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| Product Name | XL184 |
| Description | A VEGFR2 inhibitor (IC50 = 0.035 nM); selective for VEGFR2 over Ron, EGFR, IGF-1R, and EphA4/B4; inhibits c-Met, RET, c-Kit, Axl, FLT3, and Tie2 (IC50s = 1.3, 5.2, 4.6, 7, 11.3, and 14.3 nM, respectively); inhibits VEGF-induced tubule formation in HMVECs at 4.6 nM; reduces HGF-induced migration and invasion of B16/F10 cells at 123 nM; induces tumor regression in an MDA-MB-231 breast cancer mouse xenograft model at 60 mg/kg; does not increase the number of pulmonary tumor foci in an MDA-MB-231 mouse metastasis model; protects primary placental fibroblasts from Zika virus infection |
| Size | 1 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | BMS-907351|Cabozantinib |
| Gene, Accession, CAS # | CAS: 849217-68-1 |
| Catalog # | 18464-1 |
| Price | $44.00 |
| Order / More Info | XL184 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
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