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Product Name | RN-1734 |
Description | A TRPV4 antagonist (IC50s = 2.3, 5.9, and 3.2 µM for human, mouse, and rat, respectively), selective for TRPV4 over TRPV1, TRPV3, and TRPM8 (IC50s = >100, >30, and >30 µM, respectively), reduces GSK1016790A-induced increases in IGly from 34.5 to 0.97% in mouse hippocampal neurons in vitro (10 µM); blocks GSK1016790A-induced arteriolar dilation and increases myogenic tone in rat cremaster arterioles ex vivo (30 µM), reduces edema and MAPK signaling induced by traumatic brain injury in rats (1 mg/kg, i.p.), inhibits breakdown of the blood-retinal barrier in streptozotocin-induced diabetic rats (100 µM) |
Size | 25 mg |
Concentration | n/a |
Applications | n/a |
Other Names | RN1734 TRPV -4 1 3 TRPM-8 GSK-1016790A |
Gene, Accession, CAS # | CAS: 946387-07-1 |
Catalog # | 24205-25 |
Price | $220 |
Order / More Info | RN-1734 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |