DUB-IN-3 from CAYMAN CHEMICAL COMPANY

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Product NameDUB-IN-3
DescriptionAn inhibitor of USB8 (IC50 = 0.56 µM); selective for USP8 over USP7 (IC50 = >100 µM); an inhibitor of SARS-CoV-2 PLpro when Z-LRGG-AMC is used as a substrate (IC50 = 12.5 µM) but not when Ub-AMC is used as a substrate (IC50 = >10 µM); reduces GSH levels and cystine uptake, as well as increases ferrous iron and ROS levels, in HCCLM3 cells at 0.2 or 0.5 µM; decreases viability of HCCLM3 cells when used with RSL3, an effect that can be blocked by ferrostatin-1; reduces the proliferation, migration, and oncosphere formation ability of HCCLM3 and Hep3B hepatocellular carcinoma cells at 0.1 and 0.2 µM; reduces tumor growth and metastasis in HCCLM3 and Hep3B mouse models of metastatic lung cancer at 5 mg/kg per day
Size100 mg
Concentrationn/a
Applicationsn/a
Other NamesDeubiquitinase Inhibitor 3|Deubiquitinase-IN-3|DUBs Inhibitor 3|DUBs-IN-3|HBX 90397
Gene, Accession, CAS #CAS: 924296-17-3
Catalog #41594-100
Price$1,890.00
Order / More InfoDUB-IN-3 from CAYMAN CHEMICAL COMPANY
Product Specific Referencesn/a
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640

Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com

http://www.caymanchem.com

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