Methysergide (maleate) from CAYMAN CHEMICAL COMPANY
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| Product Name | Methysergide (maleate) |
| Description | A 5-HT1 receptor agonist and 5-HT2 receptor antagonist; binds to recombinant human 5-HT1A (KD = 23.44 nM), 5-HT1E (Ki = 229.09 nM), 5-HT1F (Ki = 33.88 nM), and rodent 5-HT1B receptors (KD = 1,513.56 nM); binds to recombinant human 5-HT2A (Ki = 2.69 nM) and 5-HT2C receptors (KD = 1.26 nM) and is an insurmountable antagonist at 5-HT2B receptors; inhibits 5-HT-induced vasoconstriction in isolated postmortem human basilar arterial spiral strips (pA2 = 8.07); decreases external carotid blood flow in a dose-dependent manner in vagosympathectomized dogs; has antinociceptive activity in mouse models of pain induced by substance P, glutamate, NMDA, AMPA, or kainic acid; reduces zymosan-induced paw edema in rats at 10 mg/kg |
| Size | 1 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | Desernil|NSC 186061 |
| Gene, Accession, CAS # | CAS: 129-49-7 |
| Catalog # | 27658-1 |
| Price | $32.00 |
| Order / More Info | Methysergide (maleate) from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
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