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Product Name | A-769662 |
Description | A direct activator of AMPK (EC50 = 116 nM in a cell-free assay); allosterically activates AMPK and inhibits its dephosphorylation on Thr172; activates β1 subunit-containing AMPK heterotrimers; has been used to stimulate CYP450-mediated fatty acid oxidation, inhibit adipocyte differentiation, explore glucose uptake in skeletal muscle, and promote endothelial cell survival during metabolic stress |
Size | 25 mg |
Concentration | n/a |
Applications | n/a |
Other Names | obesity syndromes kinases diabetes atherosclerosis AMP-activated proteins kinases AMPK lipids metabolisms glucose metabolic stress activators activates active glucose uptakes diseases A769662 A-769662 A 769662 A769,662 A 769,662 A-792,662 thienopyridone inhibits inhibiting inhibitions inhibitors CYP450 fatty acids oxidations adipocytes differentiations uptake up-take alpha .alpha. a beta .beta. b gamma .gamma. g heterotrimers sensors regulates regulating cells cellular energy homeostasis small molecules thienopyridones cell-free assays intact allosterically Thr172 stimulates CYP450-mediated cytochromes P450 dephosphorylations skeletal muscles endothelium endothelial |
Gene, Accession, CAS # | CAS: 844499-71-4 |
Catalog # | 11900-25 |
Price | $242.00 |
Order / More Info | A-769662 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |