Apilimod from CAYMAN CHEMICAL COMPANY
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| Product Name | Apilimod |
| Description | An inhibitor of PIKfyve (IC50 = 14 nM); is selective for PIKfyve over 10 other lipid kinases and 31 other protein kinases (IC50s = >9.1 µM for all); inhibits the production of IL-12p40 induced by IFN-γ and LPS or R-837 in isolated human PBMCs (IC50s = 2.4 and 3 nM, respectively) and the production of IL-23 induced by IFN-γ and SAC in isolated human PBMCs (IC50 = 10 nM); prevents infection of Vero E6 cells by SARS-CoV-2 (EC50 = 23 nM); reduces cell viability in a panel of B cell non-Hodgkin lymphoma cell lines (mean IC50 = 142 nM); decreases disease severity in a CD4+CD45Rbhigh T cell transfer mouse model of IBD at 10 mg/kg; decreases disease severity in a mouse model of IRBP1-20-induced experimental autoimmune uveoretinitis |
| Size | 25 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | STA-5326 |
| Gene, Accession, CAS # | CAS: 541550-19-0 |
| Catalog # | 19094-25 |
| Price | $149.00 |
| Order / More Info | Apilimod from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
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