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Product Name | VX-745 |
Description | A p38α MAPK inhibitor (IC50 = 9 nM); selective for p38α over p38β MAPK (Ki = 220 nM) as well as ERK, JNK, and a panel of 50 kinases at 2 µM; inhibits LPS-induced production of IL-1β and TNF-α in isolated human PBMCs (IC50s = 45 and 51 nM, respectively); reduces disease severity in a type II collagen-induced mouse model of arthritis at 10 mg/kg |
Size | 10 mg |
Concentration | n/a |
Applications | n/a |
Other Names | Neflamapimod |
Gene, Accession, CAS # | CAS: 209410-46-8 |
Catalog # | 18075-10 |
Price | $199.00 |
Order / More Info | VX-745 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |