VTP-50469 from CAYMAN CHEMICAL COMPANY
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| Product Name | VTP-50469 |
| Description | An inhibitor of the menin-MLL1 fusion protein interaction (Ki = 0.104 nM); selectively inhibits the growth of ten leukemia cell lines expressing MLL1 fusion proteins (IC50s = 13-37 nM) over HL-60, K562, and Reh leukemia cells expressing wild-type MLL1 (IC50s = >1000 nM); reduces MLL-AF9-induced increases in the expression of MLL fusion protein target genes in MOLM-13 leukemia cells; dramatically increases the survival of mice in a PDX mouse model of B-ALL at 120 mg/kg twice per day |
| Size | 5 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | VTP50469 MLL 1 HL60 K 562 MLLAF9 MEIS 1 MEF 2C JMJD 1C PB X3 MOLM13 BALL |
| Gene, Accession, CAS # | CAS: 2169916-18-9 |
| Catalog # | 40759-5 |
| Price | $209.00 |
| Order / More Info | VTP-50469 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
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