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Product Name | CAY10746 |
Description | A ROCK1 and ROCK2 inhibitor (IC50s = 14 and 3 nM, respectively); selective for ROCK1 and ROCK2 over PKA (IC50 = >10,000 nM) and over 387 recombinant human protein kinases in a panel of 394 kinases (IC50s = >10,000 nM for all) but does inhibit LIMK2, Aurora A, Aurora B, PKG1α, and PKG1β (IC50s = 46, 1,072, 1,239, 517, and 660 nM, respectively); inhibits phosphorylation of MYPT1 in SH-SY5Y cells at 0.1-10 µM; inhibits HUVEC migration at 1 µM; protects isolated mouse retinal neurons from apoptosis and oxidative stress induced by high glucose in an in vitro model of diabetic retinopathy; promotes high glucose-induced vessel regression in mouse retinal explants |
Size | 5 mg |
Concentration | n/a |
Applications | n/a |
Other Names | CAY-10746 LIMK-2 PKG-1α 1β MYPT-1 SHSY5Y |
Gene, Accession, CAS # | CAS: 2247240-76-0 |
Catalog # | 29814-5 |
Price | $684.00 |
Order / More Info | CAY10746 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |