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Product Name | A-770041 |
Description | An orally bioavailable LCK kinase inhibitor (IC50 = 0.147 µM); selective for LCK over Src, Fyn, Fgr, HCK, and Tie2 (IC50s = 9.05, 44.1, 14.1, 1.22, and >50 µM, respectively); inhibits IL-2 production induced by an anti-CD3 antibody and PMA in isolated human whole blood (EC50 = 80 nM) and by concanavalin A in rats; prevents acute rejection and increases graft survival in a rat model of heterotopic heart transplantation at 10 mg/kg; inhibits the growth of CTV-1 cells (IC50 = 224 nM) and sensitizes U2OSMR and KHOSR2 multidrug resistant human osteosarcoma cells to paclitaxel and doxorubicin |
Size | 1 mg |
Concentration | n/a |
Applications | n/a |
Other Names | A770041 IL2 Tie 2 antiCD3 12 myrisate 13acetate concanavalinA CTV1 osteo sarcoma |
Gene, Accession, CAS # | CAS: 869748-10-7 |
Catalog # | 32854-1 |
Price | $57.00 |
Order / More Info | A-770041 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |