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Product Name | PF-07321332 |
Description | An inhibitor of SARS-CoV-2 Mpro (Ki = 3.11 nM); inhibits Mpro from SARS-CoV-1, HKU1-CoV, OC43-CoV, and MERS-CoV (Kis = 4.94, 189, 36.4, and 187 nM, respectively), as well as Mpro from NL-63-CoV and 229E CoV (Kis = 226 and 44.4 nM, respectively); selective for these enzymes over several other proteases, including human and HIV-1 proteases (IC50s = >100 µM for all), as well as a panel of G protein-coupled receptors, kinases, and transporters (IC50s = ≥100 µM for all); inhibits SARS-CoV-2 replication in A549 cells (EC50 = 77.9 nM) and reduces the cytopathic effect of SARS-CoV-2 in infected Vero E6 cells (EC50 = 74.5 nM); reduces lung viral titers and the severity of pulmonary lesions in mice infected with the mouse-adapted SARS-CoV-2 MA10 variant at 300 and 1,000 mg/kg |
Size | 25 mg |
Concentration | n/a |
Applications | n/a |
Other Names | Nirmatrelvir |
Gene, Accession, CAS # | CAS: 2628280-40-8 |
Catalog # | 35257-25 |
Price | $998 |
Order / More Info | PF-07321332 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |