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Product Name | Calprotectin, Human, Recombinant |
Description | Calprotectin, also known as MRP-8/MRP-14 or S100A8/A9 heterocomplex, is formed out of the calcium-binding, migration inhibitory factor-related proteins, MRP-8 (S100A8) and MRP-14 (S100A9). The expression of these proteins is largely confined to the cytosol of neutrophils and monocytes. The complex formation of these proteins is calcium-dependent. Calprotectin comprises 60% of the cytoplasmic protein fraction of circulating polymorphonuclear granulocytes and is also found in monocytes, macrophages and ileal tissue eosinophils. Peripheral blood monocytes carry the antigen extra- and intracellularly, neutrophils only intracellularly. Calprotectin has antibacterial, antifungal, immunomodulating and antiproliferative effects. Furthermore, it is a potent chemotactic factor for neutrophils. Plasma concentrations are elevated in diseases associated with increased neutrophil activity. During intestinal wall inflammation, granulocytes transmigrate through the intestinal wall. Therefore calprotec |
Size | 50 µg |
Concentration | n/a |
Applications | Functional studies. RUO |
Other Names | n/a |
Gene, Accession, CAS # | n/a |
Catalog # | HC2120-50UG |
Price | $569 |
Order / More Info | Calprotectin, Human, Recombinant from HYCULT BIOTECH |
Product Specific References | n/a |