Edit |   |
---|---|
Product Name | Recombinant TNF-alpha |
Description | Sequence: 78-234aa. Purity >90% by SDS-PAGE. TNF-alpha, also known as tumor necrosis factor, is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that plays a central role in inflammation, apoptosis, and immune system development. This protein is produced by a wide variety of immune and epithelial cell types. It is assembled intracellularly to form a noncovalently linked homotrimer which is expressed on the cell surface. Cell surface TNF can induce the lysis of neighboring tumor cells and virus infected cells, and it can generate its own downstream cell signaling following ligation by soluble TNFR I. It also promotes inflammatory responses by inducing the activation of vascular endothelial cells and macrophages. Re. MW: 17.5 kDa (158aa) confirmed by MALDI-TOF |
Size | 0.02 mg, 0.1 mg |
Concentration | 1mg/ml (determined by Bradford assay) |
Applications | Bioactivity, SDS-PAGE |
Other Names | [Tumor necrosis factor; TNF-a; TNF; TNFa], [TNF; TNF; TNFa; TNF-a; TNF-alpha; TNFA; TNFSF2; TNF-a; NTF; ICD1; ICD2] |
Gene, Accession, CAS # | [TNF-alpha], Gene ID: 280943, NCBI: NP_776391.2, UniProt: Q06599 |
Catalog # | MBS201122 |
Price | $255, $485 |
Order / More Info | Recombinant TNF-alpha from MYBIOSOURCE INC. |
Product Specific References | Bojarojc-Nosowicz B., et al (2015). Pol J Vet Sci. 18(3): 533-9. Lendez PA., et al (2015). Arch Virol. 160(8): 2001-7. |