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Product Name | Recombinant Human respiratory syncytial virus A Fusion glycoprotein F0 (F), partial |
Description | Sequence: 27-529aa. Purity >85% as determined by SDS-PAGE. During virus entry, induces fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. The fusogenic activity is inactive untill entry into host cell endosome, where a furin-like protease cleaves off a small peptide between F1 and F2. Interacts directly with heparan sulfate and may participate in virus attachment. Furthermore, the F2 subunit was identifed as the major determinant of RSV host cell specificity. Later in infection, proteins F expressed at the plasma membrane of infected cells can mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis. The fusion protein is also able to trigge. MW: 60.8 kDa |
Size | 0.01 mg (E-Coli), 0.05 mg (E-Coli), 0.1 mg (E-Coli) |
Concentration | n/a |
Applications | n/a |
Other Names | [Fusion glycoprotein F0; Fusion glycoprotein F0] |
Gene, Accession, CAS # | [F], NCBI: P11209.2, UniProt: P11209 |
Catalog # | MBS7110919 |
Price | $200, $260, $430 |
Order / More Info | Recombinant Human respiratory syncytial virus A Fusion glycoprotein F0 (F), partial from MYBIOSOURCE INC. |
Product Specific References | Structural characterization of the human respiratory syncytial virus fusion protein core. Zhao X., Singh M., Malashkevich V.N., Kim P.S.Proc. Natl. Acad. Sci. U.S.A. 97:14172-14177 (2000) |