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Product Name | Recombinant MDL-1/CLEC5A |
Description | Sequence: 28-188aa. Purity >90% by SDS-PAGE. CLEC5A, also known as C-type lectin domain family 5 member A isoform 1, is a member of the CTL/CTLD superfamily that have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. It functions as a cell attachment receptor for all four serotypes of Dengue virus as well as Japanese encephalitis virus. The binding of dengue virus to CLEC5A triggers signaling through the phosphylation of TYROBP, this interaction does not result in viral entry, but stimulates proinflammatory cytokine release. This protein acts as a positive regulator of osteoclastogenesis and a key regulator of synovial injury and bone erosion during autoimm. MW: 19.5kDa (170aa); 28-40KDa (SDS-PAGE under reducing conditions) |
Size | 0.01 mg, 0.05 mg |
Concentration | 0.25mg/ml (determined by Absorbance at 280nm) |
Applications | SDS-PAGE |
Other Names | [C-type lectin domain family 5 member A isoform 1; CLEC5A; CLECSF5; MDL-1; MDL1], [CLEC5A; CLEC5A; MDL1; MDL-1; CLECSF5; CLECSF5; MDL1; MDL-1] |
Gene, Accession, CAS # | [MDL-1/CLEC5A], Gene ID: 23601, NCBI: Q9NY25.1, UniProt: Q9NY25 |
Catalog # | MBS201085 |
Price | $310, $925 |
Order / More Info | Recombinant MDL-1/CLEC5A from MYBIOSOURCE INC. |
Product Specific References | Gonzalez-Dominguez E., et al, (2015) J Leukoc Biol. 98:453-466. Chen ST., et al, (2017) Nat Commun. 8:299. |