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Product Name | Recombinant human PCBP1 protein |
Description | Domain: 1-163aa. Recombinant human PCBP1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. MW: 19.6 kDa (186aa) confirmed by MALDI-TOF. Purity > 85% by SDS-PAGE. PCBP1 appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly (rC) -binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promotes poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. PCBP1 is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability |
Size | 20ug, 100ug, 500ug |
Concentration | 1mg/ml (determined by Bradford assay) |
Applications | SDS-PAGE |
Other Names | Poly(rC) binding protein 1, Poly(rC) binding protein 1, hnRNP-E1, hnRNP-X, HNRPE1, HNRPX |
Gene, Accession, CAS # | NCBI: NP_006187, UniProt: Q15365 |
Catalog # | ATGP2314 |
Price | $80, $240, $720 |
Order / More Info | Recombinant human PCBP1 protein from NKMAX Co. Ltd. |
Product Specific References | n/a |