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Product Name | Recombinant SARS-CoV Spike RBD protein |
Description | Domain: 306-515aa. Recombinant SARS-CoV spike RBD protein fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques. MW: 24.8kDa (220aa). Purity > 95% by SDS - PAGE. Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV), and the recently identified novel Coronavirus (SARS-CoV-2) belong to the Coronaviridae family, genus Betacoronavirus, that has been related to important epidemiological outbreaks. SARS-CoV emerged in 2003 as a significant threat to human health. SARS-CoV has four structural proteins, known as the S (spike), E (envelope), M (membrane), and N (nucleocapsid) proteins. The spike protein, responsible for allowing the virus to attach to and fuse with the membrane of a host cell and is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. It attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. A metallopeptidase, angiotensin-converting enzyme 2 (ACE-2), has been identified as a functional receptor for SARS-CoV through interaction with a receptor binding domain (RBD) located at the C-terminus of S1 subunit |
Size | 10ug, 20ug, 50ug, 100ug, 250ug, 500ug, 1mg |
Concentration | 0.5 mg/ml (determined by Absorbance at 280nm) |
Applications | SDS-PAGE, Bioactivity |
Other Names | E2 glycoprotein precursor, Spike glycoprotein, S glycoprotein, E2, Peplomer protein, Severe acute repiratory Syndrome-related Coronavirus, SARS, SRAS-CoV, SARS-CoV1 |
Gene, Accession, CAS # | NCBI: NP_828851.1, UniProt: P59594 |
Catalog # | ATGP3966 |
Price | $108, $198, $261, $432, $765, $1305, $2178 |
Order / More Info | Recombinant SARS-CoV Spike RBD protein from NKMAX Co. Ltd. |
Product Specific References | n/a |