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Product Name | RF-Absorbent |
Description | RF Absorbent is for the removal of IgM- rheumatoid factors from serum- and plasma-probes or cerebrospinal fluid (CSF) which are to be prepared for the detection of specific IgM-antibodies in indirect Immunoassays. Rheumatoid factors are predominantly anti-IgG directed autoantibodies of the IgM class that can be detected in serum samples of approximately 5% of healthy individuals. Those IgM rheumatoid factors preferably bind to IgG immune complexes. Therefore, false-positive results may appear in pathogen-specific IgM detection. In samples with a high concentration of pathogen-specific IgG antibodies, weakly binding IgM antibodies may be displaced by stronger binding IgG antibodies. In those cases, IgM detection without RF-absorption can lead to false-negative results. Therefore, it is necessary to pretreat serum samples with RF-absorbens. Prior to pathogen-specific IgM detection, it precipitates up to 15 mg IgG/ml undiluted serum and thereby also IgG binding IgM rheumatoid factors. |
Size | 20 ml |
Concentration | n/a |
Applications | Immunoassays |
Other Names | n/a |
Gene, Accession, CAS # | n/a |
Catalog # | Z200 |
Price | $85 |
Order / More Info | RF-Absorbent from QED BIOSCIENCE INC. |
Product Specific References | n/a |