Edit |   |
---|---|
Product Name | AKT/PKBa Substrate |
Description | >98% specific peptide. Akt is a serine/threonine kinase that enhances cell proliferation and inhibits apoptosis when activated. Akt associates with PI(3,4,5)P3) at the cell membrane through its pleckstrin homology domain and is activated through phosphorylation. 3-Phosphoinositide-dependent kinase-1 (PDK1) has been shown to first phosphorylate Akt at Thr308, then a second kinase phosphorylates Akt at position Ser473. In turn, Akt phosphorylates a host of proteins including the proapoptotic proteins BAD and pro-caspase-9, GSK3, p21WAF1, MDM2, and the forkhead (FKHR) family of transcription factors. |
Size | 500 µg |
Concentration | 1.0 mg/mL |
Applications | Western Blot |
Other Names | AKT1, serine/threonine kinase, apoptosis inhibitor substrate peptides, blocking peptide, control peptide |
Gene, Accession, CAS # | AKT1 |
Catalog # | 000-000-260 |
Price | $233 |
Order / More Info | AKT/PKBa Substrate from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |