WSU MONOCLONAL ANTIBODY CENTER Profile

Research universities, research institutes and industry established core facilities to exploit mAb technology to develop mAbs for use as analytical tools in the biological and biomedical sciences, in the characterization of the immune system, study the mechanisms by which pathogens cause disease, develop improved diagnostic assays, and identify antigens from pathogens that can be used in subunit vaccines. Because of our research needs, we started developing mAbs for use in food and companion animal research and diagnostic medicine in 1979. To encourage other investigators to use mAb technology, we sponsored the first international symposium and workshop ‘Impact of Monoclonal Antibody Technology on Animal and Plant Agricultural Research’ in June of 1982. We also participated in a workshop sponsored by the National Research Council of the National Academy of Science on ‘Priorities in Biotechnology Research for International Development held in July of 1982, a symposium sponsored by the USDA ‘Hybridoma Technology in Agricultural and Veterinary Research’ held in Oct. of 1983 and an international conference sponsored by the International Laboratory for Research on Animal Diseases ‘The Ruminant Immune System In Health and Disease’ held in Kenya Africa in September 1983. In 1984, we co-sponsored a meeting with Australia ‘Characterization of the Bovine Immune System and the Genes Regulating Expression of Immunity with Particular Reference to their Role in Disease Resistance’ held in Honolulu, Hawaii. During this period of time, we developed some of the first sets of mAbsfor use in the study of the immune system in food and companion animals. We also participated in all the international workshops to characterize the first sets of mAbs.

The Washington State University Monoclonal Antibody Center was established in 1982 with the following goals:

1 Provide a central facility for the production of mAbs for investigators that do not have the facilities or expertise to produce mAbs for their research.

2 Develop and use mAbs to study the mechanisms regulating the immune response to pathogens and candidate subunit vaccines in veterinary species.

3 Provide a source of mAbs for the research community for use in food and companion animal research.

4 Provide graduate and professional training in the use of mAb technology in research and the development of diagnostic reagents.

5 Provide graduate and professional training in the use of mAbs in immunology and flow cytometry.

6 Collaborate with investigators requiring expertise and resources available through the center to conduct studies in immunology.

7 Aid in the development of clinical flow cytometry diagnostic services in veterinary medicine.